LukemanLab Science: Introduction

We are interested in nanometer-scale control of chemical functionality : this enables
the synthesis of new materials,
the discovery of new chemical and biochemical reactions,
the ability to direct the organization of nanoelectronic components
and control of molecular motion for elementary nanorobotics.

DNA-based nanotechnology controls chemical functionality at the nanometer scale using designed,
synthetic, self-assembled systems that are unique in their versatility and programmability.

A great introduction to DNA-based nanotechnology for laypepople can be found here

LukemanLab Science: Our Plans

Our projects involve the use of covalent chemistry to control DNA-based nanotechnology. We will

a) Make DNA nanoconstructions that are more robust with respect to temperature, pH and metal ion concentration -
allowing them to be used in a wider range of environments
b) Enable orthogonal chemical and physical stimuli to activate and deactivate DNA sequence-controlled switches -
enabling greater control of the design and operation of these systems
c) Develop systems that allow the control of multiple DNA switches without the addition of external reagents -
enabling the use of these switches in multiplexed self-contained sensing environments

More details will follow success at these endeavors.