Tuesday, February 20, 2007
(Note: Special date, place, and time)
A biophysical Model of Angiogenesis: How Do Growing Tumors Feed and Breathe?
National Institutes of Health
Angiogenesis, the growth of new blood vessels, is a crucial process in
tumor growth. New vessels allow tumors to receive additional nutrients,
and also provide a pathway for tumor cells to enter the bloodstream and
spread to the rest of the body. In attempt to help clinicians disrupt
this process, many physicists have begun quantitative studies of
tumor-induced angiogenesis. After outlining the basic elements of this
process, I will present a model for the diffusion of Vascular
Endothelial Growth Factor (VEGF, a key chemical involved in
angiogenesis) and its interaction with the tissue. I will use the model
to show that only one form of VEGF is distributed throughout the tissue
in a manner that can efficiently guide blood vessels towards the tumor.
Our model is consistent with experimental observations concerning the
different forms of VEGF, it casts serious doubt on a common hypothesis
in the literature, and it is suitable for experimental confirmation with
simple in vitro studies. I will also discuss possible extensions of
this work, including projects suitable for undergraduate researchers.
Refreshments at 11:00 AM. Seminar begins at 11:10 AM.
Building 4, Room 1-314
For further information, please call (909) 869-4014