Membrane Transport Journal Club

Date	Discussion Leader	Paper to be Discussed
5/9/2008	Rana Moosavi	Kniazeff, J., Shi, L., Loland, C.J., Javitch, J.A., Weinstein, H., Gether, U. 2008. An intracellular interaction network regulates conformational transitions in the dopamine transporter. J. Biol. Chem. DOI:10.1074/jbc.M800475200.
5/2/2008	Matt Maestas	Kragler, A., Höfner, G., Wanner, K.T. 2008. Synthesis and biological evaluation of aminomethylphenol derivatives as inhibitors of the murine GABA transporters mGAT1-mGAT4. Eur. J. Med. Chem. DOI:10.1016/j.ejmech.2008.01.005.
4/25/2008	Steve Byrne	Rosenberg, A., Kanner, B.I. 2008. The substrates of the GABA transporter GAT-1 induce structural rearrangements around the interface of transmembrane domains 1 and 6. J. Biol. Chem. DOI:10.1074/jbc.M801093200.
4/18/2008	Rick Kidd	Bartholomaeus, I., Milan-Lobo, L., Nicke, A., Dutertre, S., Hastrup, H., Jha, A., Gether, U., Sitte, H.H., Betz, H., Eulenburg, V. 2008. Glycine transporter dimers: Evidence for occurrence in the plasma membrane. J. Biol. Chem. 283, 10978-10991.
3/14/2008	Eddie Matthews	Zhou, Y., Zomot, E., Kanner, B.I. 2006. Identification of a lithium interaction site in the γ-aminobutyric acid (GABA) transporter GAT-1. J. Biol. Chem. 281, 22092-22099.
3/7/2008	Rana Moosavi	Erreger, K., Grewer, C., Javitch, J.A., Galli, A. 2008. Currents in response to rapid concentration jumps of amphetamine uncover novel aspects of human dopamine transporter function. J. Neurosci. 28, 976-989.
11/30/2007	Matt Maestas	Smith, C.G., Bowery, N.G., Whitehead, K.J. 2007. GABA transporter type 1 (GAT-1) uptake inhibition reduces stimulated aspartate and glutamate release in the dorsal spinal cord in vivo via different GABAergic mechanisms. Neuropharmacology doi:10.1016/j.neuropharm.2007.09.008
11/16/2007	Steve Byrne	Hu, J., Quick M.W. 2007. Substrate-mediated regulation of γ-aminobutyric acid transporter 1 in rat brain. Neuropharmacology doi:10.1016/j.neuropharm.2007.09.013
11/9/2007	Ray Oropeza	Palló, A., Bencsura, A., Héja, L., Beke, T., Perczel, A., Kardos, J., Simon, A. 2007. Major human γ-aminobutyrate transporter: In silico prediction of substrate efficacy. Biochem. Biophys. Res. Commun. doi:10.1016/j.bbrc.2007.10.108
11/2/2007	Eddie Matthews	Tartaglione, C.M., Ritta, M.N. 2007. On the presence of ³H-GABA uptake mechanism in bovine spermatozoa. Anim. Reprod. Sci. doi:10.1016/j.anireprosci.2007.08.010
10/12/2007	Rick Kidd	Zomot, E., Bendahan, A., Quick, M., Zhao, Y., Javitch, J.A., Kanner, B.I. 2007. Mechanism of chloride interaction with neurotransmitter:sodium symporters. Nature doi:10.1038/nature06133
8/23/2007	Ray Oropeza	Farhan, H., Reiterer, V., Korkhov, V.M., Schmid, J.A., Freissmuth, M., Sitte, H.H. 2007. Concentrative export from the endoplasmic reticulum of the γ-aminobutyric acid transporter 1 requires binding to SEC24D. J. Biol. Chem. 282, 7679–7689.
8/9/2007	Sep Eskandari	Forrest, L.R., Tavoulari, S., Zhang, Y.W., Rudnick, G., Honig, B. 2007. Identification of a chloride ion binding site in Na⁺/Cl^--dependent transporters. Proc. Natl. Acad. Sci. USA 104, 12761–12766
7/6/2007	Matt Maestas	Wu, Q., Wada, M., Shimada, A., Yamamoto, A., Fujita, T. (2006) Functional characterization of Zn²⁺-sensitive GABA transporter expressed in primary cultures of astrocytes from rat cerebral cortex. Brain Res. 1075, 100-109.
6/22/2007	Ray Oropeza	Lu, C.-C., Hilgemann, D.W. (1999) GAT1 (GABA:Na⁺:Cl^-) cotransport function. Steady state studies in giant Xenopus oocyte membrane patches. J. Gen. Physiol. 114, 429-444.
6/1/2007	Matt Maestas	Christiansen, B., Meinild, A.K., Jensen, A.A., Brauner-Osborne, H. (2007) Cloning and characterization of a functional human γ-aminobutyric acid (GABA) transporter, human GAT-2. J. Biol. Chem. In press.
5/25/2007	Rick Kidd	Dodd, J.R., Christie, D.L. (2007) Selective amino acid substitutions convert the creatine transporter to a γ-aminobutyric acid transporter. J. Biol. Chem. In press.
5/11/2007	Sep Eskandari	Hu, J.H., He, X.B., Yan, Y.C. (2000) Identification of γ-aminobutyric acid transporter (GAT1) on the rat sperm. Cell Res. 10, 51-58.
5/4/2007	Matt Maestas	Aanesen, A., Fried, G., Andersson, E., Gottlieb, C. (1996) Carrier-mediated γ-aminobutyric acid uptake in human spermatozoa indicating the presence of a high-affinity γ-aminobutyric acid transport protein. Biol. Reprod. 54, 841-846.
4/27/2007	Ray Oropeza	Bicho, A., Grewer, C. (2005) Rapid substrate-induced charge movements of the GABA transporter GAT1. Biophys J. 89, 211-231.
3/9/2007	Jerry Ku	Sipila, S.T., Voipio, J., Kaila, K. (2007) GAT-1 acts to limit a tonic GABA_A current in rat CA3 pyramidal neurons at birth. Eur. J. Neurosci. 25, 717-722.
2/16/2007	Rick Kidd	Beuming, T., Shi, L., Javitch, J.A., Weinstein, H. (2006) A comprehensive structure-based alignment of prokaryotic and eukaryotic neurotransmitter/Na⁺ symporters (NSS) aids in the use of the LeuT structure to probe NSS structure and function. Mol. Pharmacol. 70, 1630-1642.
2/9/2007	Ray Oropeza	Wu, Y., Wang, W., Richerson, G.B. (2006) The transmembrane sodium gradient influences ambient GABA concentration by altering the equilibrium of GABA transporters. J. Neurophysiol. 96, 2425-2436.